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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SOCS3
All Species:
22.12
Human Site:
Y168
Identified Species:
44.24
UniProt:
O14543
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14543
NP_003946.3
225
24770
Y168
P
R
R
A
Y
Y
I
Y
S
G
G
E
K
I
P
Chimpanzee
Pan troglodytes
XP_509267
198
22155
A142
D
K
R
T
G
P
E
A
P
R
N
G
T
V
H
Rhesus Macaque
Macaca mulatta
XP_001106015
576
62574
Y519
P
R
R
A
Y
Y
I
Y
S
G
G
E
K
I
P
Dog
Lupus familis
XP_848851
225
24779
Y168
P
R
R
A
Y
Y
I
Y
S
G
G
E
K
I
P
Cat
Felis silvestris
Mouse
Mus musculus
O35718
225
24758
Y168
P
K
R
A
Y
Y
I
Y
S
G
G
E
K
I
P
Rat
Rattus norvegicus
O88583
225
24790
Y168
P
K
R
A
Y
Y
I
Y
S
G
G
E
K
I
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516256
214
23730
S158
K
R
T
Y
Y
I
Y
S
G
G
E
K
I
P
L
Chicken
Gallus gallus
Q90X67
209
23158
S153
K
R
T
Y
Y
I
Y
S
G
G
E
K
I
P
L
Frog
Xenopus laevis
P13116
532
59718
K441
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
Zebra Danio
Brachydanio rerio
NP_998469
210
23421
S154
G
S
A
Y
F
I
Y
S
G
G
E
K
I
P
L
Tiger Blowfish
Takifugu rubipres
NP_001072096
201
22742
S145
S
T
L
Y
Y
I
Y
S
G
A
E
K
V
P
L
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799032
227
25956
P169
G
Q
L
V
W
L
E
P
S
G
R
K
D
T
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28
38.5
97.7
N.A.
96.8
95.5
N.A.
79.5
84
20.1
61.3
57.3
N.A.
N.A.
N.A.
35.2
Protein Similarity:
100
45.3
38.8
99.1
N.A.
97.3
96.4
N.A.
86.2
88.4
28.2
74.6
70.6
N.A.
N.A.
N.A.
52.4
P-Site Identity:
100
6.6
100
100
N.A.
93.3
93.3
N.A.
20
20
13.3
6.6
6.6
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
26.6
26.6
20
20
13.3
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
42
0
0
0
9
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
0
9
0
0
9
0
0
% D
% Glu:
0
0
0
0
0
0
17
0
0
0
34
42
0
0
9
% E
% Phe:
0
0
0
0
17
0
0
0
0
0
0
0
0
9
0
% F
% Gly:
17
0
9
0
9
0
0
0
34
75
42
9
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
0
0
0
0
34
50
0
0
0
0
0
25
42
0
% I
% Lys:
17
25
0
0
0
0
0
9
0
0
0
42
42
0
0
% K
% Leu:
9
0
17
0
0
9
0
0
0
0
0
0
0
0
34
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% N
% Pro:
42
0
0
0
0
9
0
9
9
0
0
0
0
34
42
% P
% Gln:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
42
50
9
0
0
0
0
0
9
9
0
0
0
0
% R
% Ser:
9
9
0
0
0
0
0
34
59
0
0
0
9
0
0
% S
% Thr:
0
9
17
9
0
9
0
0
0
0
0
0
9
9
0
% T
% Val:
0
0
0
9
0
0
0
0
0
0
9
0
9
9
0
% V
% Trp:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% W
% Tyr:
0
9
0
34
67
42
34
42
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _